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KMID : 0371320060700020091
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Journal of the Korean Surgical Society
2006 Volume.70 No. 2 p.91 ~ p.97
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Expression of E-cadherin in pT2 Lesion of Gastric Cancer
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Yang Hwa-Yeun
Koo Bon-Uk
Yun Hyo-Yung
Ryu Dong-Hee
Song Young-Jin
Kim Seok-Hyung
Eom Sang-Yong
Kim Heon
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Abstract
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Purpose: Abnormal expression of E-cadherin has been shown to play a role in the progression and the metastasis of tumors. We investigated the correlation between the expressions of E-cadherin and the clinicopathologic factors and survival in pT2 gastric adenocarcinomas.
Methods: We examined formalin-fixed, paraffin-embedded archival tissues from 100 surgically resected gastric adenocarcinomas with pT2 lesion. Tissue preparations were stained with Zymed’s monoclonal mouse anti-E-cadherin (clone: 4A2C7). We analyzed the correlation between the expressions of E-cadherin and clinicopathologic factors.
Results: Normal gastric mucosa was immunoreactive with anti-E-cadherin antibody. Among the 100 tumors examined, 73 tumors showed expression of E-cadherin. The gender, age, size, depth of invasion, lymph node metastasis, stage (UICC), lymphatic invasion, vascular invasion were not related with E-cadherin expression but Lauren classification and histologic type were strongly correlated with E-cadherin expression (P=0.000, P=0.006). Though patients with decreased expression of E-cadherin showed a poorer median survival than normal expression (43.85±23.95 months vs. 61.27±33.47 months), expression of E-cadherin was not related with survival rate (P=0.668).
Conclusion: In patients with gastric cancer, expressions of E-cadherin correlated with histologic type and Lauren classification but not with survival. (J Korean Surg Soc 2006; 70:91-97)
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KEYWORD
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E-cadherin, Gastric adenocarcinoma, Immunohistochemistry
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